Insulin-like 6 immunoreactivity in the mouse brain and testis

G Cristina Brailoiu; Siok L Dun; Deling Yin; Jun Yang; Jaw Kang Chang; Nae J Dun

doi:10.1016/j.brainres.2005.01.077

Insulin-like 6 immunoreactivity in the mouse brain and testis

Brain Res. 2005 Apr 8;1040(1-2):187-90. doi: 10.1016/j.brainres.2005.01.077.

Authors

G Cristina Brailoiu¹, Siok L Dun, Deling Yin, Jun Yang, Jaw Kang Chang, Nae J Dun

Affiliation

¹ Department of Pharmacology, Temple University School of Medicine, 3420 N. Broad Street, Philadelphia, PA 19140, USA.

PMID: 15804440
DOI: 10.1016/j.brainres.2005.01.077

Abstract

Insulin-like 6 immunoreactivity (irINSL6) was detected in Leydig cells of the mouse testis. In the brain, labeled somata were detected mainly in the caudal hypothalamus and midbrain. Double labeling the brainstem sections revealed that irINSL6 somata were 5-hydroxytryptamine (5-HT) positive. The presence of irINSL6 in discrete populations of hypothalamic and brainstem neurons and in Leydig cells of the testis suggests a diverse biological function of this novel peptide.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
Brain / metabolism
Brain Chemistry / physiology*
Female
Immunohistochemistry
Insulin / analogs & derivatives*
Insulin / analysis*
Insulin / biosynthesis
Intercellular Signaling Peptides and Proteins
Intracellular Signaling Peptides and Proteins
Male
Mice
Mice, Inbred ICR
Testis / chemistry*
Testis / metabolism

Substances

Insl6 protein, mouse
Insulin
Intercellular Signaling Peptides and Proteins
Intracellular Signaling Peptides and Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding