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    Muscle Nerve. 2005 Aug;32(2):230-5.

    Isolated vitamin E deficiency with demyelinating neuropathy.

    Source

    Department of Neurology, G. B. Pant Hospital, New Delhi 110002, India.

    Abstract

    A 22-year-old man, with a past history of generalized tonic-clonic seizures treated with phenobarbital, presented with spinocerebellar ataxia. The electrophysiological studies revealed a demyelinating motor-sensory neuropathy. The serum vitamin E level was low. Sural nerve biopsy revealed loss of large myelinated fibers with evidence of remyelination. Vitamin E supplementation led to clinical and electrophysiological recovery of sensory conduction and evoked potentials. Motor nerve conduction, however, showed only partial recovery. Vitamin E deficiency leading to a demyelinating neuropathy, as in the present case, suggests that the full spectrum of the disease entity is not fully defined.

    PMID:
    15803482
    [PubMed - indexed for MEDLINE]

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