How do thiazide and thiazide-like diuretics lower ...[J Renin Angiotensin Aldosterone Syst. 2004]

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1: J Renin Angiotensin Aldosterone Syst. 2004 Dec;5(4):155-60. Links

How do thiazide and thiazide-like diuretics lower blood pressure?

Hughes AD.

Clinical Pharmacology, Faculty of Medicine, Imperial College London, London W21NY, UK. a.hughes@imperial.ac.uk

Thiazide diuretics are widely used for the treatment of hypertension, but the mechanism by which these drugs lower blood pressure in the long term remains unknown. This article reviews current knowledge about the hypotensive actions of thiazides and thiazide-like diuretics and discusses possible mechanisms of action.

PMID: 15803433 [PubMed - indexed for MEDLINE]

Torasemide in comparison with thiazides in the treatment of hypertension. [Cardiovasc Drugs Ther. 1993]
Sympatho-adrenal mechanisms and the antihypertensive response to thiazide diuretics. [Acta Pharmacol Toxicol (Copenh). 1984]
Current concepts of pharmacotherapy in hypertension: thiazide-type diuretics: ongoing considerations on mechanism of action. [J Clin Hypertens (Greenwich). 2004]
[Diuretics for therapy of patients with hypertension] [Nippon Rinsho. 1997]
Comparison of indapamide with thiazide diuretics in patients with essential hypertension. [Med J Aust. 1981]
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How do thiazide and thiazide-like diuretics lower blood pressure?

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