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Nat Rev Neurosci. 2005 Apr;6(4):325-31.

Statins--a cure-all for the brain?

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  • 1Department of Neurology, University of California San Francisco, 505 Parnassus Avenue, Box 0114, San Francisco, California 94143-0114, USA.


'Statins' are 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors - oral cholesterol-lowering drugs that are used to treat hypercholesterolaemia. It is widely accepted that statins have anti-inflammatory effects that are independent of their ability to lower cholesterol. Animal studies and observational clinical studies have indicated that statins might also be effective in treating certain neurological diseases - in particular, multiple sclerosis, Alzheimer's disease and ischaemic stroke. At present, however, results from ongoing prospective, randomized clinical trials are not available.

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