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Nat Rev Mol Cell Biol. 2005 Apr;6(4):287-97.

IAPs, RINGs and ubiquitylation.

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  • 1The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3050, Australia. vaux@wehi.edu.au

Abstract

The inhibitor of apoptosis (IAP) proteins all contain one or more baculoviral IAP repeat motifs, through which they interact with various other proteins. Many IAPs also have another zinc-binding motif, the RING domain, which can recruit E2 ubiquitin-conjugating enzymes and catalyse the transfer of ubiquitin onto target proteins. The number of targets of IAP-mediated ubiquitylation is increasing and recent results indicate that outcomes following ubiquitylation are tantalizingly complex. As well as regulating other proteins, the IAPs themselves are controlled by ubiquitin-mediated degradation.

PMID:
15803136
[PubMed - indexed for MEDLINE]
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