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    Mol Cell Biol. 2005 Apr;25(8):3109-16.

    Coupling of human circadian and cell cycles by the timeless protein.

    Unsal-Kaçmaz K, Mullen TE, Kaufmann WK, Sancar A.

    Department of Biochemistry and Biophysics, Mary Ellen Jones Building CB 7260, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.

    The Timeless protein is essential for circadian rhythm in Drosophila. The Timeless orthologue in mice is essential for viability and appears to be required for the maintenance of a robust circadian rhythm as well. We have found that the human Timeless protein interacts with both the circadian clock protein cryptochrome 2 and with the cell cycle checkpoint proteins Chk1 and the ATR-ATRIP complex and plays an important role in the DNA damage checkpoint response. Down-regulation of Timeless in human cells seriously compromises replication and intra-S checkpoints, indicating an intimate connection between the circadian cycle and the DNA damage checkpoints that is in part mediated by the Timeless protein.

    PMID: 15798197 [PubMed - indexed for MEDLINE]

    PMCID: 1069621

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