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Chem Biol. 2005 Mar;12(3):262-3.

Adding specificity to artificial transcription activators.

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  • 1Department of Chemistry, New York University, New York, NY 10012, USA.


In this issue, Mapp and colleagues describe a significant advance in the design of artificial transcription activators that function in a cell-type-specific manner. [1] The authors show that peptides selected for binding a component of the yeast transcription complex require its presence for effective transcriptional activation.

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