Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Genet Dev. 2005 Apr;15(2):200-5.

MicroRNAs: a developing story.

Author information

  • 1Molecular Biology Section, Division of Biology 0349, Bonner Hall Rm. 4118, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0349, USA. apasquin@ucsd.edu

Abstract

Considering the intense genetic efforts applied to understanding development, it is surprising that a relatively large class of regulatory genes has newly surfaced. The first microRNA gene and its developmental role were described more than ten years ago, but only recently have we fully appreciated the broad and abundant presence of such genes. MicroRNAs are approximately 22 nucleotide RNAs that use antisense complementarity to inhibit expression of specific mRNAs. Recent studies of restricted expression patterns and functional roles have implicated specific microRNAs in complex genetic pathways regulating embryogenesis, hematopoiesis, neuronal differentiation and Hox-mediated development.

PMID:
15797203
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk