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Curr Biol. 2005 Mar 29;15(6):R203-5.

Synaptogenesis: a balancing act between excitation and inhibition.

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  • 1Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY 11724, USA.


Recent studies have implicated a number of membrane-associated proteins, including the signaling pair neuroligin and beta-neurexin, in synapse formation, suggesting that they govern the ratio of inhibitory and excitatory synapses on CNS neurons. These findings, together with data indicating that the genes encoding neuroligin and PSD95 are altered in autism patients, suggest that a molecular understanding of complex neurological diseases is within reach.

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