Send to

Choose Destination
See comment in PubMed Commons below
Nucleic Acids Res. 1992 Apr 25;20(8):1909-15.

The yeast UME6 gene product is required for transcriptional repression mediated by the CAR1 URS1 repressor binding site.

Author information

  • 1Department of Microbiology and Immunology, University of Tennessee, Memphis 38163.


URS1 is known to be a repressor binding site in Saccharomyces cerevisiae that negatively regulates expression of many genes including CAR1 (arginase), several required for sporulation, mating type switching, inositol metabolism, and oxidative carbon metabolism. In addition to the proteins previously shown to directly bind to the URS1 site, we show here that the UME6 gene product is required for URS1 to mediate repression of gene expression in the absence of inducer. We also show that mutations in the CAR80 (CARGRI) gene are allelic to those in UME6.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk