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Nat Genet. 2005 Apr;37(4):349-50. Epub 2005 Mar 27.

Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.

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  • 1Institut National de la Santé et de la Recherche Médicale, Avenir Group, Laboratory of Genomic Biology, Centre Paul Broca, 75014 Paris, France.

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  • Nat Genet. 2005 May;37(5):555.


We report that Sir2 activation through increased sir-2.1 dosage or treatment with the sirtuin activator resveratrol specifically rescued early neuronal dysfunction phenotypes induced by mutant polyglutamines in transgenic Caenorhabditis elegans. These effects are dependent on daf-16 (Forkhead). Additionally, resveratrol rescued mutant polyglutamine-specific cell death in neuronal cells derived from HdhQ111 knock-in mice. We conclude that Sir2 activation may protect against mutant polyglutamines.

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