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1: Nat Genet. 2005 Apr;37(4):349-50. Epub 2005 Mar 27.Click here to read Links
Erratum in:
Nat Genet. 2005 May;37(5):555.
Comment in:
Nat Genet. 2005 Apr;37(4):339-40.

Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.

Parker JA, Arango M, Abderrahmane S, Lambert E, Tourette C, Catoire H, Néri C.

Institut National de la Santé et de la Recherche Médicale, Avenir Group, Laboratory of Genomic Biology, Centre Paul Broca, 75014 Paris, France.

We report that Sir2 activation through increased sir-2.1 dosage or treatment with the sirtuin activator resveratrol specifically rescued early neuronal dysfunction phenotypes induced by mutant polyglutamines in transgenic Caenorhabditis elegans. These effects are dependent on daf-16 (Forkhead). Additionally, resveratrol rescued mutant polyglutamine-specific cell death in neuronal cells derived from HdhQ111 knock-in mice. We conclude that Sir2 activation may protect against mutant polyglutamines.

PMID: 15793589 [PubMed - indexed for MEDLINE]