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Nano Lett. 2005 Jan;5(1):49-54.

Composite organic-inorganic nanoparticles (COINs) with chemically encoded optical signatures.

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  • 1Biotechnology Research Group, Intel Research and CTM, Intel Corporation, SC2-24, 2200 Mission College Boulevard, Santa Clara, California 95054, USA.


To obtain a coding system for multiplex detection, we have developed a method to synthesize a new type of nanomaterial called composite organic-inorganic nanoparticles (COINs). The method allows the incorporation of a broad range of organic compounds into COINs to produce surface enhanced Raman scattering (SERS)-like spectra that are richer in variety than fluorescence-based signatures. Preliminary data suggest that COINs can be used as Raman tags for multiplex and ultrasensitive detection of biomolecules.

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