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Opt Lett. 2005 Mar 15;30(6):625-7.

In vivo dark-field reflection-mode photoacoustic microscopy.

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  • 1Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A&M University, College Station, Texas 77843-3120, USA.


Reflection-mode photoacoustic microscopy with dark-field laser pulse illumination and high-numerical-aperture ultrasonic detection is designed and implemented in noninvasively imaged blood vessels in the skin in vivo. Dark-field optical illumination minimizes the interference caused by strong photoacoustic signals from superficial structures. A high-numerical-aperture acoustic lens provides high lateral resolution, 45-120 microm in this system. A broadband ultrasonic detection system provides high axial resolution, estimated to be approximately 15 microm. The optical illumination and ultrasonic detection are in a coaxial confocal configuration for optimal image quality. The system is capable of imaging optical-absorption contrast as deep as 3 mm in biological tissue.

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