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Nature. 1992 May 14;357(6374):128-34.

ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex.

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  • 1Cold Spring Harbor Laboratory, New York 11724.

Abstract

A multiprotein complex that specifically recognizes cellular origins of DNA replication has been identified and purified from the yeast Saccharomyces cerevisiae. We observe a strong correlation between origin function and origin recognition by this activity. Interestingly, specific DNA binding by the origin recognition complex is dependent upon the addition of ATP. We propose that the origin recognition complex acts as the initiator protein for S. cerevisiae origins of DNA replication.

[PubMed - indexed for MEDLINE]
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