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Clin Infect Dis. 2005 Apr 15;40(8):1194-8. Epub 2005 Mar 17.

Changes in renal function associated with tenofovir disoproxil fumarate treatment, compared with nucleoside reverse-transcriptase inhibitor treatment.

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  • 1The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.


In our large observational cohort, use of tenofovir disoproxil fumarate (n=344) was associated with a greater decline in renal function than was use of alternative nucleoside analogues (n=314). Other associations included a lower CD4 cell count, decreased renal function at baseline, and diabetes. The declines were modest and did not lead to greater rates of discontinuation of therapy.

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