Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Science. 2005 May 20;308(5725):1149-54. Epub 2005 Mar 24.

Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution.

Author information

  • 1Affymetrix Inc., Santa Clara, CA 95051, USA.

Abstract

Sites of transcription of polyadenylated and nonpolyadenylated RNAs for 10 human chromosomes were mapped at 5-base pair resolution in eight cell lines. Unannotated, nonpolyadenylated transcripts comprise the major proportion of the transcriptional output of the human genome. Of all transcribed sequences, 19.4, 43.7, and 36.9% were observed to be polyadenylated, nonpolyadenylated, and bimorphic, respectively. Half of all transcribed sequences are found only in the nucleus and for the most part are unannotated. Overall, the transcribed portions of the human genome are predominantly composed of interlaced networks of both poly A+ and poly A- annotated transcripts and unannotated transcripts of unknown function. This organization has important implications for interpreting genotype-phenotype associations, regulation of gene expression, and the definition of a gene.

PMID:
15790807
[PubMed - indexed for MEDLINE]
Free full text

MeSH Terms, Substances, Secondary Source ID

MeSH Terms

Substances

Secondary Source ID

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire
    Loading ...
    Write to the Help Desk