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Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):4936-42. Epub 2005 Mar 23.

Gene regulatory networks for development.

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  • 1Department of Molecular and Cell Biology, 401 Barker Hall, University of California, Berkeley, CA 94720, USA.

Abstract

The genomic program for development operates primarily by the regulated expression of genes encoding transcription factors and components of cell signaling pathways. This program is executed by cis-regulatory DNAs (e.g., enhancers and silencers) that control gene expression. The regulatory inputs and functional outputs of developmental control genes constitute network-like architectures. In this PNAS Special Feature are assembled papers on developmental gene regulatory networks governing the formation of various tissues and organs in nematodes, flies, sea urchins, frogs, and mammals. Here, we survey salient points of these networks, by using as reference those governing specification of the endomesoderm in sea urchin embryos and dorsal-ventral patterning in the Drosophila embryo.

PMID:
15788537
[PubMed - indexed for MEDLINE]
PMCID:
PMC555974
Free PMC Article

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