Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Nat Prod. 2005 Mar;68(3):331-6.

Cytotoxic sterol derivatives from a marine sponge Homaxinella sp.

Author information

  • 1College of Pharmacy, Pusan National University, Busan 609-735, Korea.

Abstract

A bioactivity-guided fractionation of a marine sponge Homaxinella sp. has led to the isolation of three new (1-3) highly degraded sterols and four new 6-O-alkylated (6-9) sterols, along with known sterol derivatives. The degraded sterols (1-5) belong to the class incisterols, previously isolated from the marine sponge Dictyonella incisa. Mainly NMR and MS spectroscopic analyses established the gross structures of the new compounds. The relationship between the stereoisomerism of the side chain and HPLC retention time has also been discussed. The compounds were tested against a panel of five human solid tumor cell lines, and especially the degraded sterols (1-4) displayed significant cytotoxicity.

PMID:
15787431
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Chemical Society
    Loading ...
    Write to the Help Desk