[Change of dopamine transporter activity (DAT) during the action of bupropion (in depression)]

Zoltán Szabó; Miklós Argyelán; Balázs Kanyó; László Pávics; Zoltán Janka

[Change of dopamine transporter activity (DAT) during the action of bupropion (in depression)]

Neuropsychopharmacol Hung. 2004 Jun;6(2):79-81.

[Article in Hungarian]

Authors

Zoltán Szabó¹, Miklós Argyelán, Balázs Kanyó, László Pávics, Zoltán Janka

Affiliation

¹ Szegedi Tudományegyetem, Pszichiátriai Klinika.

PMID: 15787205

Abstract

Bupropion has an antidepressant effect through blocking the dopamine transporter. By 99mTc-TRODAT-SPECT, we measured the baseline DAT activity of depressed patients. After 3 weeks' bupropion treatment we studied the change in DAT activity, which corresponds to the occupancy of bupropion. The average occupancy of bupropion on DAT was similar to the international findings at 20.84% in 9 depressed patients.

Publication types

English Abstract

MeSH terms

Adult
Antidepressive Agents, Second-Generation / pharmacology
Bupropion / administration & dosage
Bupropion / pharmacology*
Depressive Disorder, Major / drug therapy*
Depressive Disorder, Major / metabolism*
Dopamine Plasma Membrane Transport Proteins
Dopamine Uptake Inhibitors / administration & dosage
Dopamine Uptake Inhibitors / pharmacology*
Female
Humans
Male
Membrane Glycoproteins / drug effects*
Membrane Transport Proteins / drug effects*
Middle Aged
Nerve Tissue Proteins / drug effects*
Organotechnetium Compounds*
Radiopharmaceuticals
Tomography, Emission-Computed, Single-Photon* / methods
Tropanes*

Substances

Antidepressive Agents, Second-Generation
Dopamine Plasma Membrane Transport Proteins
Dopamine Uptake Inhibitors
Membrane Glycoproteins
Membrane Transport Proteins
Nerve Tissue Proteins
Organotechnetium Compounds
Radiopharmaceuticals
SLC6A3 protein, human
Tropanes
technetium Tc 99m TRODAT-1
Bupropion