Biosci Biotechnol Biochem. 2005 Mar;69(3):448-54.

Potential ability of hot water adzuki (Vigna angularis) extracts to inhibit the adhesion, invasion, and metastasis of murine B16 melanoma cells.

Source

Imuraya Confectionary Co., Ltd., Tsu, Mie, Japan. chuken@imuraya.co.jp

Abstract

The 40% ethanol eluent of the fraction of hot-water extract from adzuki beans (EtEx.40) adsorbed onto DIAION HP-20 resin has many biological activities, for example, antioxidant, antitumorigenesis, and intestinal alpha-glucosidase suppressing activities. This study examined the inhibitory effect of EtEx.40 on experimental lung metastasis and the invasion of B16-BL6 melanoma cells. EtEx.40 was found significantly to reduce the number of tumor colonies. It also inhibited the adhesion and migration of B16-BL6 melanoma cells into extracellular matrix components and their invasion into reconstituted basement membrane (matrigel) without affecting cell proliferation in vitro. These in vivo data suggest that EtEx.40 possesses a strong antimetastatic ability, which might be a lead compound in functional food development.

PMID:: 15784970; [PubMed - indexed for MEDLINE]

Free full text

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

J-STAGE, Japan Science and Technology Information Aggregator, Electronic

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

Alpha-melanocyte-stimulating hormone blocks invasion of reconstituted basement membrane (Matrigel) by murine B16 melanoma cells. [Invasion Metastasis. 1997]
Alpha-melanocyte-stimulating hormone blocks invasion of reconstituted basement membrane (Matrigel) by murine B16 melanoma cells.
Murata J, Ayukawa K, Ogasawara M, Fujii H, Saiki I. Invasion Metastasis. 1997; 17(2):82-93.
Hot-water extracts from adzuki beans (Vigna angularis) stimulate not only melanogenesis in cultured mouse B16 melanoma cells but also pigmentation of hair color in C3H mice. [Biosci Biotechnol Biochem. 2005]
Hot-water extracts from adzuki beans (Vigna angularis) stimulate not only melanogenesis in cultured mouse B16 melanoma cells but also pigmentation of hair color in C3H mice.
Itoh T, Furuichi Y. Biosci Biotechnol Biochem. 2005 May; 69(5):873-82.
Inhibition of tumor invasion and metastasis by calcium spirulan (Ca-SP), a novel sulfated polysaccharide derived from a blue-green alga, Spirulina platensis. [Clin Exp Metastasis. 1998]
Inhibition of tumor invasion and metastasis by calcium spirulan (Ca-SP), a novel sulfated polysaccharide derived from a blue-green alga, Spirulina platensis.
Mishima T, Murata J, Toyoshima M, Fujii H, Nakajima M, Hayashi T, Kato T, Saiki I. Clin Exp Metastasis. 1998 Aug; 16(6):541-50.
Review Investigation of the antimetastatic effects of agents that inhibit cell adhesion or protein glycosylation. [J Natl Med Assoc. 1987]
Review Investigation of the antimetastatic effects of agents that inhibit cell adhesion or protein glycosylation.
Humphries MJ, Matsumoto K, White SL, Olden K. J Natl Med Assoc. 1987 Apr; 79(4):411-9.
Review Cell-cell and cell-extracellular matrix interactions during melanoma cell invasion and metastasis. [Melanoma Res. 1993]
Review Cell-cell and cell-extracellular matrix interactions during melanoma cell invasion and metastasis.
Edward M, MacKie RM. Melanoma Res. 1993 Aug; 3(4):227-34.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

Potential ability of hot water adzuki (Vigna angularis) extracts to inhibit the ...
Potential ability of hot water adzuki (Vigna angularis) extracts to inhibit the adhesion, invasion, and metastasis of murine B16 melanoma cells.
Biosci Biotechnol Biochem. 2005 Mar ;69(3):448-54.

PubMed
Incidence of cervical squamous intraepithelial lesions associated with HIV seros...
Incidence of cervical squamous intraepithelial lesions associated with HIV serostatus, CD4 cell counts, and human papillomavirus test results.
JAMA. 2005 Mar 23 ;293(12):1471-6.

PubMed
Changes in financial strain over three years, ambulatory blood pressure, and cor...
Changes in financial strain over three years, ambulatory blood pressure, and cortisol responses to awakening.
Psychosom Med. 2005 Mar-Apr ;67(2):281-7.

PubMed
Inflammatory markers and sleep disturbance in major depression.
Inflammatory markers and sleep disturbance in major depression.
Psychosom Med. 2005 Mar-Apr ;67(2):187-94.

PubMed
What ails the FDA?
What ails the FDA?
N Engl J Med. 2005 Mar 17 ;352(11):1063-6.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: