J Pediatr. 1992 May;120(5):799-802.

Cardiotoxic effects of astemizole overdose in children.

Wiley JF 2nd, Gelber ML, Henretig FM, Wiley CC, Sandhu S, Loiselle J.

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Section of General Pediatrics, St. Christopher's Hospital for Children, Philadelphia, Pennsylvania.

Abstract

Astemizole, a nonsedating antihistamine, caused a prolonged corrected QT interval, ventricular dysrhythmias, and atrioventricular heart block after overdose in five children. Cardiotoxic effects lasted an average of 2 1/2 days. Children poisoned with astemizole need emergent medical evaluation, a 12-lead electrocardiogram with calculation of the corrected QT interval, and continuous cardiac monitoring for 24 hours.

PMID:: 1578320; [PubMed - indexed for MEDLINE]

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