Abstract
The human carcinoembryonic antigen (CEA) is overexpressed in many types of human cancers and is commonly used as a clinical marker. In colon cancer, this overexpression protects cells against apoptosis and contributes to carcinogenesis. Therefore, CEA-expressing cells as well as CEA expression itself constitute potential therapeutic targets. In this report, we show that the transcription factor SOX9 down-regulates CEA gene expression and, as a probable consequence, induces apoptosis in the human colon carcinoma cell line HT29Cl.16E.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Apoptosis / physiology
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Carcinoembryonic Antigen / biosynthesis
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Carcinoembryonic Antigen / genetics*
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Cell Differentiation / physiology
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Colonic Neoplasms / genetics*
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Colonic Neoplasms / immunology
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Colonic Neoplasms / pathology
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Down-Regulation / physiology
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Gene Expression Regulation, Neoplastic / physiology*
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HT29 Cells
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High Mobility Group Proteins / biosynthesis
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High Mobility Group Proteins / genetics
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High Mobility Group Proteins / physiology*
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Humans
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Promoter Regions, Genetic
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SOX9 Transcription Factor
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Transcription Factors / biosynthesis
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Transcription Factors / genetics
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Transcription Factors / physiology*
Substances
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Carcinoembryonic Antigen
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High Mobility Group Proteins
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SOX9 Transcription Factor
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SOX9 protein, human
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Transcription Factors