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Vaccine. 2005 Apr 15;23(21):2696-702.

Vaccines for otitis media: proposals for overcoming obstacles to progress.

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  • 1Division of Infectious Diseases, Department of Medicine, University at Buffalo, SUNY, USA.


Otitis media is a common problem with enormous morbidity worldwide. The development of vaccines to prevent otitis media would have an important human and economic impact. A striking lack of progress in the development, production and clinical testing of vaccines to prevent otitis media has occurred in the past decade. This review outlines a series of specific proposals intended to advance vaccine development for otitis media.

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