The role of group 1 and group 2 CD1-restricted T cells in microbial immunity.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Smith Building Room 516C, One Jimmy Fund Way, Boston, MA 02115, USA.

Group 1 and group 2 CD1 present both self and microbial lipid antigens to T cells. While group 1 CD1-restricted T cells are known for their ability to recognize mycobacterial glycolipid antigens, group 2 CD1-restricted T cells are recognized as regulatory T cells that can influence the outcome of innate and adaptive immune responses. The evidence that these T cells contribute to host defense against infectious diseases is reviewed.

PMID: 15777730 [PubMed - indexed for MEDLINE]