Intron-exon organization of the NF-Y genes. Tissue...[J Biol Chem. 1992]

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1: J Biol Chem. 1992 May 5;267(13):8984-90. Links

Intron-exon organization of the NF-Y genes. Tissue-specific splicing modifies an activation domain.

Li XY, Hooft van Huijsduijnen R, Mantovani R, Benoist C, Mathis D.

Laboratoire de Génétique Moléculaire des Eucaryotes du Centre National de la Recherche Scientifique, Unité 184 de Biologie Moléculaire, Strasbourg, France.

NF-Y is a highly conserved transcription factor which recognizes CCAAT motifs in a variety of genes. We report here the genomic organization of the genes encoding both subunits, which gives interesting clues about the functional organization of the proteins. We also report the existence of isoforms of NF-YA which result from differential splicing. These alternative splicing events map within a glutamine-rich activation domain and show a marked cell- and tissue-specific bias.

PMID: 1577736 [PubMed - indexed for MEDLINE]

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