Abstract
Cell-associated proteoglycans provide highly complex and sophisticated systems to control interactions of extracellular cell matrix components and soluble ligands with the cell surface. Syndecans, a conserved family of heparan- and chondroitin-sulfate carrying transmembrane proteins, are emerging as central players in these interactions. Recent studies have demonstrated the essential role of syndecans in modulating cellular signaling in embryonic development, tumorigenesis, and angiogenesis. In this review, we focus on new advances in our understanding of syndecan-mediated cell signaling.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Cell Movement / physiology
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Chondroitin Sulfates / chemistry
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Chondroitin Sulfates / physiology
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Cytoskeleton / physiology
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Embryonic Development / physiology
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Endocytosis / physiology
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Extracellular Matrix / physiology
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Gene Expression Regulation
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Growth Substances / chemistry
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Growth Substances / physiology
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Heparitin Sulfate / chemistry
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Heparitin Sulfate / physiology
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Humans
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Membrane Glycoproteins / chemistry
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Membrane Glycoproteins / physiology*
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Mice
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Morphogenesis / physiology
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Neovascularization, Physiologic / physiology
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Protein Binding
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Protein Conformation
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Protein Kinase C / physiology
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Protein Kinase C-alpha
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Protein Structure, Tertiary
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Proteoglycans / chemistry
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Proteoglycans / physiology*
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Signal Transduction / physiology*
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Structure-Activity Relationship
Substances
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Growth Substances
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Membrane Glycoproteins
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Proteoglycans
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Chondroitin Sulfates
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Heparitin Sulfate
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PRKCA protein, human
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Prkca protein, mouse
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Protein Kinase C
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Protein Kinase C-alpha