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Genome Biol. 2005;6(3):210. Epub 2005 Feb 28.

Connecting the dots in Huntington's disease with protein interaction networks.

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  • 1Department of Pharmacology, University of Washington, Seattle, WA 98195, USA.

Abstract

Analysis of protein-protein interaction networks is becoming important for inferring the function of uncharacterized proteins. A recent study using this approach has identified new proteins and interactions that might be involved in the pathogenesis of the neurodegenerative disorder Huntington's disease, including a GTPase-activating protein that co-localizes with protein aggregates in Huntington's disease patients.

PMID:
15774033
[PubMed - indexed for MEDLINE]
PMCID:
PMC1088934
Free PMC Article

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