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1: Genome Biol. 2005;6(3):210. Epub 2005 Feb 28.Click here to read Click here to read Links

Connecting the dots in Huntington's disease with protein interaction networks.

Giorgini F, Muchowski PJ.

Department of Pharmacology, University of Washington, Seattle, WA 98195, USA.

Analysis of protein-protein interaction networks is becoming important for inferring the function of uncharacterized proteins. A recent study using this approach has identified new proteins and interactions that might be involved in the pathogenesis of the neurodegenerative disorder Huntington's disease, including a GTPase-activating protein that co-localizes with protein aggregates in Huntington's disease patients.

PMID: 15774033 [PubMed - indexed for MEDLINE]

PMCID: PMC1088934