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    FEBS Lett. 1992 Apr 27;301(3):319-21.

    Isolation and primary structure of a novel chromogranin A-derived peptide, WE-14, from a human midgut carcinoid tumour.

    Curry WJ, Shaw C, Johnston CF, Thim L, Buchanan KD.

    Department of Medicine, Queen's University of Belfast, N. Ireland, UK.

    The primary structure of a novel human chromogranin A-derived tetradecapeptide, WE-14, possessing N-terminal tryptophanyl (W) and C-terminal glutamyl (E) residues was isolated from a hepatic metastasis of an human ileal carcinoid tumour. Human and bovine WE-14 are structurally identical, while rat, mouse and porcine analogues exhibit 93% homology. WE-14 is flanked by paired basic residues (KR) in all known chromogranin A sequences.

    PMID: 1577173 [PubMed - indexed for MEDLINE]

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