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Annu Rev Immunol. 2005;23:901-44.

Macrophage receptors and immune recognition.

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  • 1Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom, USA.

Abstract

Macrophages express a broad range of plasma membrane receptors that mediate their interactions with natural and altered-self components of the host as well as a range of microorganisms. Recognition is followed by surface changes, uptake, signaling, and altered gene expression, contributing to homeostasis, host defense, innate effector mechanisms, and the induction of acquired immunity. This review covers recent studies of selected families of structurally defined molecules, studies that have improved understanding of ligand discrimination in the absence of opsonins and differential responses by macrophages and related myeloid cells.

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