Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cell Mol Life Sci. 2005 Mar;62(6):642-52.

Leptin receptor action and mechanisms of leptin resistance.

Author information

  • 1Division of Metabolism, Endocrinology and Diabetes, Departments of Internal Medicine and Molecular and Physiology, University of Michigan Medical School, 1150 W. Medical Center Dr., 4301 MSRB 3, Box 0638, Ann Arbor, Michigan, 48109-0638, USA.

Abstract

The adipose tissue-derived hormone leptin regulates energy balance and neuroendocrine function. Resistance to the appetite-suppressing effects of leptin is associated with common forms of obesity. Here, we review the mechanisms by which leptin activates intracellular signals and the roles that these signals play in leptin action in vivo. Furthermore, we discuss potential mechanisms of leptin resistance, specifically focusing on data regarding the neuroanatomical locus of leptin resistance and potential mechanisms by which expression of the suppressor of cytokine signaling-3 may impair leptin action.

PMID:
15770417
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Write to the Help Desk