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Zhonghua Liu Xing Bing Xue Za Zhi. 2004 Dec;25(12):1024-7.

[Effect of chemotherapy on the control of schistosomiasis Japonicum].

[Article in Chinese]

Author information

  • 1Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China.

Abstract

OBJECTIVE:

To study the effect of infection control on schistosomasis Japonicum based on selective chemotherapy.

METHODS:

Data were derived from national surveillance of schistosomiasis from 2000 to 2002, and random effect model of Meta-analysis was used to analyze the effect of chemotherapy on controlling schistosomiasis infection.

RESULTS:

One year after chemotherapy was started in the pilot villages where infection rate of schistosomiasis was more than 10%, the infection rates among residents and eggs per gram (EPG) of patients as well as population (geometric mean, GM) significantly reduced by 20.15%, 22.91% and 33.93% with 95% confidence interval (CI) 6.95 - 31.48, 14.69 - 30.34 and 11.69 - 50.68 respectively. In the pilot villages where infection rates were between 6% and 10%, the control measures largely base on chemotherapy significantly reduced the infection rate, by 24.50 (95% CI: 5.35 - 39.83). However the infection rates were no longer reduced in the pilot villages where the infection rate was less than 6%; EPG of patients and residents were maintained at the original level in the pilot villages where infection rate was 10% or less.

CONCLUSION:

In China, the rates of schistosomiasis Japonicum infection could be effectively reduced through the control measures largely based on chemotherapy, and they were kept at a relatively low level. However, it was very difficult to interrupt the transmission of schistosomiasis.

PMID:
15769355
[PubMed - indexed for MEDLINE]
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