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Curr Opin Immunol. 2005 Apr;17(2):108-15.

Gammadelta T cell development--having the strength to get there.

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  • 1Peter Gorer Department of Immunobiology, Guy's King's St. Thomas' Medical School, King's College, Guy's Hospital, London SE1 9RT, UK. Daniel.Pennington@kcl.ac.uk


Gammadelta T cells play critical roles in immune regulation, tumour surveillance and specific primary immune responses. Mature gammadelta cells derive from thymic precursors that also generate alphabeta T cells. Recent reports have highlighted the impact of the strength of signal received via the T cell receptor on T cell lineage commitment, and the importance of cross-talk between committed alphabeta thymocytes and bipotential progenitors for normal gammadelta T cell differentiation. Studies on T cell receptor-mediated selection of gammadelta cells have supported the view that these unconventional T cells are positively rather than negatively selected on cognate self antigen.

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