Cephalalgia. 1992 Apr;12(2):81-4.

Sodium valproate in the prophylactic treatment of migraine: a double-blind study versus placebo.

Source

Department of Neurology, Beilinson Medical Center, Petach Tikva, Israel.

Abstract

The efficacy of sodium valproate (Depalept) versus placebo in the treatment of migraine was evaluated in a double-blind randomized cross-over study in twenty-nine patients. The patients were divided into two groups each of which was alternately given 400 mg of sodium valproate B.I.d or placebo for eight weeks and then crossed over for an additional eight weeks. Our results show that in 86.2% of the patients sodium valproate was effective in preventing migraine or reducing the frequency, severity and duration of the attacks. In general, the drug was well tolerated and proved to be an effective treatment in migraine.

Comment in

Cephalalgia. 1992 Apr;12(2):67.

PMID:: 1576648; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Valproic Acid

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Molecular Biology Databases

VALPROIC ACID - HSDB

Supplemental Content

Save items

Related citations in PubMed

Sodium valproate has a prophylactic effect in migraine without aura: a triple-blind, placebo-controlled crossover study. [Neurology. 1994]
Sodium valproate has a prophylactic effect in migraine without aura: a triple-blind, placebo-controlled crossover study.
Jensen R, Brinck T, Olesen J. Neurology. 1994 Apr; 44(4):647-51.
Vestibulo-ocular reflex in migraine patients: the effect of sodium valproate. [Headache. 1993]
Vestibulo-ocular reflex in migraine patients: the effect of sodium valproate.
Gordon CR, Kuritzky A, Doweck I, Spitzer O, Shupak A, Hering R. Headache. 1993 Mar; 33(3):129-32.
Divalproex sodium in migraine prophylaxis: a dose-controlled study. [Cephalalgia. 1997]
Divalproex sodium in migraine prophylaxis: a dose-controlled study.
Klapper J. Cephalalgia. 1997 Apr; 17(2):103-8.
Review [Valproic acid in prophylactic treatment of migraine]. [Nervenarzt. 1998]
Review [Valproic acid in prophylactic treatment of migraine].
Arnold G, Einhäupl KM. Nervenarzt. 1998 Oct; 69(10):913-8.
Review Divalproex sodium in headache: literature review and clinical guidelines. [Headache. 1996]
Review Divalproex sodium in headache: literature review and clinical guidelines.
Silberstein SD. Headache. 1996 Oct; 36(9):547-55.

See reviews... See all...

Cited by 10 PubMed Central articles

Review Prophylaxis of migraine headache. [CMAJ. 2010]
Review Prophylaxis of migraine headache.
Pringsheim T, Davenport WJ, Becker WJ. CMAJ. 2010 Apr 20; 182(7):E269-76. Epub 2010 Feb 16.
Optimizing prophylactic treatment of migraine: Subtypes and patient matching. [Ther Clin Risk Manag. 2008]
Optimizing prophylactic treatment of migraine: Subtypes and patient matching.
Dib M. Ther Clin Risk Manag. 2008 Oct; 4(5):1061-78.
Investigation of gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility. [BMC Med Genet. 2008]
Investigation of gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility.
Fernandez F, Esposito T, Lea RA, Colson NJ, Ciccodicola A, Gianfrancesco F, Griffiths LR. BMC Med Genet. 2008 Dec 16; 9:109. Epub 2008 Dec 16.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Sodium valproate in the prophylactic treatment of migraine: a double-blind study...
Sodium valproate in the prophylactic treatment of migraine: a double-blind study versus placebo.
Cephalalgia. 1992 Apr ;12(2):81-4.

PubMed
[Guidelines on asbestos-related pleuropulmonary disease].
[Guidelines on asbestos-related pleuropulmonary disease].
Arch Bronconeumol. 2005 Mar ;41(3):153-68.

PubMed
Adjunctive subantimicrobial dose doxycycline: effect on clinical parameters and ...
Adjunctive subantimicrobial dose doxycycline: effect on clinical parameters and gingival crevicular fluid transforming growth factor-beta levels in severe, generalized chronic periodontitis.
J Clin Periodontol. 2005 Mar ;32(3):244-53.

PubMed
The current practice of tracheostomy in the United Kingdom: a postal survey.
The current practice of tracheostomy in the United Kingdom: a postal survey.
Anaesthesia. 2005 Apr ;60(4):360-4.

PubMed
Serine 16 phosphorylation induces an order-to-disorder transition in monomeric p...
Serine 16 phosphorylation induces an order-to-disorder transition in monomeric phospholamban.
Biochemistry. 2005 Mar 22 ;44(11):4386-96.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: