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J Clin Invest. 2005 Mar;115(3):500-8.

Oxygen, oxidative stress, hypoxia, and heart failure.

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  • 1Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA.


A constant supply of oxygen is indispensable for cardiac viability and function. However, the role of oxygen and oxygen-associated processes in the heart is complex, and they and can be either beneficial or contribute to cardiac dysfunction and death. As oxygen is a major determinant of cardiac gene expression, and a critical participant in the formation of ROS and numerous other cellular processes, consideration of its role in the heart is essential in understanding the pathogenesis of cardiac dysfunction.

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