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J Control Release. 2005 Mar 21;103(2):291-9. Epub 2005 Jan 19.

The correlation between transepidermal water loss and percutaneous absorption: an overview.

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  • 1Department of Dermatology, University of California School of Medicine, 90 Medical Center Way, Surge 110, San Francisco, CA 94143, USA.


Independently, both transepidermal water loss (TEWL) and percutaneous absorption measurements accurately gauge stratum corneum skin water barrier integrity. Both TEWL and percutaneous absorption rates increase when the integrity of the SC barrier is compromised. Experiments to discern a quantitative and/or qualitative correlation between the two indicators have resulted in controversy. This paper reviews some major studies investigating this correlation.

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