FEBS Lett. 2005 Mar 21;579(8):1867-71.

From molecular networks to qualitative cell behavior.

Source

Cellzome AG, Meyerhofstr. 1, 69117 Heidelberg, Germany. julien.gagneur@cellzome.com

Abstract

Adaptation and behavior are characteristics of life which are fundamentally dynamic. If we want to model the living cell we have to describe it as a dynamic system. Typical dynamic models are based on quantitative differential equations requiring very detailed kinetic knowledge. Alternative modeling techniques for less fine-grained information are better suited to available functional genomics data. As such, constraint-based techniques and qualitative modeling have proven themselves to be valid approaches in cell biology. These approaches offer formal support to check the consistency of molecular networks against phenotypic observations in the light of dynamic systems.

PMID:: 15763565; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

Review

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

A hybrid input-output approach to model metabolic systems: an application to intracellular thiamine kinetics. [J Biomed Inform. 2001]
A hybrid input-output approach to model metabolic systems: an application to intracellular thiamine kinetics.
Bellazzi R, Guglielmann R, Ironi L, Patrini C. J Biomed Inform. 2001 Aug; 34(4):221-48.
Application of Petri net based analysis techniques to signal transduction pathways. [BMC Bioinformatics. 2006]
Application of Petri net based analysis techniques to signal transduction pathways.
Sackmann A, Heiner M, Koch I. BMC Bioinformatics. 2006 Nov 2; 7:482. Epub 2006 Nov 2.
Computational approaches to the topology, stability and dynamics of metabolic networks. [Phytochemistry. 2007]
Computational approaches to the topology, stability and dynamics of metabolic networks.
Steuer R. Phytochemistry. 2007 Aug-Sep; 68(16-18):2139-51. Epub 2007 Jun 14.
Review Proteomic and computational methods in systems modeling of cellular signaling. [Curr Pharm Biotechnol. 2006]
Review Proteomic and computational methods in systems modeling of cellular signaling.
Kleppe R, Kjarland E, Selheim F. Curr Pharm Biotechnol. 2006 Jun; 7(3):135-45.
Review Computational approaches for modeling regulatory cellular networks. [Trends Cell Biol. 2004]
Review Computational approaches for modeling regulatory cellular networks.
Eungdamrong NJ, Iyengar R. Trends Cell Biol. 2004 Dec; 14(12):661-9.

See reviews... See all...

Cited by 5 PubMed Central articles

Communicating oscillatory networks: frequency domain analysis. [BMC Syst Biol. 2011]
Communicating oscillatory networks: frequency domain analysis.
Ihekwaba AE, Sedwards S. BMC Syst Biol. 2011 Dec 22; 5:203. Epub 2011 Dec 22.
Elucidation of functional consequences of signalling pathway interactions. [BMC Bioinformatics. 2009]
Elucidation of functional consequences of signalling pathway interactions.
Ihekwaba AE, Nguyen PT, Priami C. BMC Bioinformatics. 2009 Nov 6; 10:370. Epub 2009 Nov 6.
Inferring Drosophila gap gene regulatory network: a parameter sensitivity and perturbation analysis. [BMC Syst Biol. 2009]
Inferring Drosophila gap gene regulatory network: a parameter sensitivity and perturbation analysis.
Fomekong-Nanfack Y, Postma M, Kaandorp JA. BMC Syst Biol. 2009 Sep 21; 3:94. Epub 2009 Sep 21.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

From molecular networks to qualitative cell behavior.
From molecular networks to qualitative cell behavior.
FEBS Lett. 2005 Mar 21 ;579(8):1867-71.

PubMed
Synthetic modular systems--reverse engineering of signal transduction.
Synthetic modular systems--reverse engineering of signal transduction.
FEBS Lett. 2005 Mar 21 ;579(8):1808-14.

PubMed
How to induce physicians to engage in quality assurance activities in a universi...
How to induce physicians to engage in quality assurance activities in a university hospital: a policy.
Qual Assur Health Care. 1992 Mar ;4(1):19-24.

PubMed
Intensity modulated radiotherapy for head and neck cancer: evidence for preserve...
Intensity modulated radiotherapy for head and neck cancer: evidence for preserved salivary gland function.
Radiother Oncol. 2005 Mar ;74(3):251-8. Epub 2004 Dec 8 .

PubMed
Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (I): concepts ...
Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (I): concepts and terms in 3D image based 3D treatment planning in cervix cancer brachytherapy with emphasis on MRI assessment of GTV and CTV.
Radiother Oncol. 2005 Mar ;74(3):235-45.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: