Your browser version may not work well with NCBI's Web applications. More information here...
1: Auton Autacoid Pharmacol. 2005 Apr;25(2):79-84.Click here to read Links

Doxapram inhibits carotid sinus baroreceptors in rabbits.

Osanai S, Takahashi T, Nakano H, Kikuchi K.

First Department of Medicine, Asahikawa Medical College, 2-1-1-1 Midorigaoka Higashi, Asahikawa 078-8510, Japan.

1 To clarify the effects of doxapram on the baroreflex, we recorded carotid sinus nerve (CSN) activity in isolated and perfused carotid artery bifurcations of rabbits. 2 The CSN activity due to chemoreceptor stimulation was blocked by resection of the nerve branches from the carotid body. After the resection, the CSN activity was correlated to increase of carotid sinus (CS) pressure. 3 Administration of doxapram reduced the CSN activity originating from baroreceptors. The effect of doxapram on baroreceptors was dose dependent and reversible. 4 It is unlikely that doxapram altered CS wall mechanics because CS pressure did not change in the presence of the drug. 5 We conclude that doxapram acts on the cardiovascular system in part by inhibiting the negative feedback loop that originates in CS baroreceptors.

PMID: 15757507 [PubMed - indexed for MEDLINE]