Expert Opin Emerg Drugs. 2005 Feb;10(1):151-71.

Emerging analgesics in cancer pain management.

Source

University of Aachen, Department of Palliative Medicine, Pauwelsstrasse 30, 52074 Aachen, Germany. Lradbruch@ukaachen.de

Abstract

Cancer pain is one of the most frequent symptoms in malignant disease, severely impairing the patients' quality of life. The recommendations of the World Health Organization will provide adequate pain relief for the vast majority of cancer patients. However, some patients will suffer from inadequate analgesia or intolerable side effects. Cyclooxygenase-2 (COX-2)-selective non-steroidal anti-inflammatory drugs (NSAIDs), new anticonvulsants, cannabinoids and NMDA receptor antagonists are being developed for these patients. NSAIDs with nitric oxide-releasing moieties are an interesting addition, as this new class of analgesics combines improved analgesic efficacy with higher tolerability. Conotoxins and other drugs such as nicotinic acetylcholinergic receptor agonists will be advantageous only for a few patients in the near future, as side-effect profile and risk of complications, as well as the burden on the patient, often are not worth the additional analgesic benefit.

PMID:: 15757410; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Education

New England Research Institutes Inc.

Medical

Supplemental Content

Save items

Related citations in PubMed

Opioids and the management of chronic severe pain in the elderly: consensus statement of an International Expert Panel with focus on the six clinically most often used World Health Organization Step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone). [Pain Pract. 2008]
Opioids and the management of chronic severe pain in the elderly: consensus statement of an International Expert Panel with focus on the six clinically most often used World Health Organization Step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone).
Pergolizzi J, Böger RH, Budd K, Dahan A, Erdine S, Hans G, Kress HG, Langford R, Likar R, Raffa RB, et al. Pain Pract. 2008 Jul-Aug; 8(4):287-313. Epub 2008 May 23.
Review Emerging therapies for neuropathic pain. [Expert Opin Emerg Drugs. 2005]
Review Emerging therapies for neuropathic pain.
Collins SD, Chessell IP. Expert Opin Emerg Drugs. 2005 Feb; 10(1):95-108.
Review Recent advances in pharmacotherapy for cancer pain management. [Cancer Pract. 2002]
Review Recent advances in pharmacotherapy for cancer pain management.
Lucas LK, Lipman AG. Cancer Pract. 2002 May-Jun; 10 Suppl 1:S14-20.
Review Update on guidelines for the treatment of chronic musculoskeletal pain. [Clin Rheumatol. 2006]
Review Update on guidelines for the treatment of chronic musculoskeletal pain.
Schnitzer TJ. Clin Rheumatol. 2006; 25 Suppl 1:S22-9. Epub 2006 Jun 2.
Review Pain management today - what have we learned? [Clin Rheumatol. 2006]
Review Pain management today - what have we learned?
Langford RM. Clin Rheumatol. 2006; 25 Suppl 1:S2-8. Epub 2006 Jun 2.

See reviews... See all...

Cited by 1 PubMed Central article

Role of the cannabinoid system in pain control and therapeutic implications for the management of acute and chronic pain episodes. [Curr Neuropharmacol. 2006]
Role of the cannabinoid system in pain control and therapeutic implications for the management of acute and chronic pain episodes.
Manzanares J, Julian M, Carrascosa A. Curr Neuropharmacol. 2006 Jul; 4(3):239-57.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Emerging analgesics in cancer pain management.
Emerging analgesics in cancer pain management.
Expert Opin Emerg Drugs. 2005 Feb ;10(1):151-71.

PubMed
Downstream region of the human tyrosinase-related protein gene enhances its prom...
Downstream region of the human tyrosinase-related protein gene enhances its promoter activity.
Biochem Biophys Res Commun. 1992 Apr 30 ;184(2):568-75.

PubMed
Characteristic beta-globin gene cluster haplotypes of Evenkis and Oroqens in nor...
Characteristic beta-globin gene cluster haplotypes of Evenkis and Oroqens in north China.
Hum Biol. 2004 Oct ;76(5):765-78.

PubMed
Isolation of a hemoglobin-derived opioid peptide from cerebrospinal fluid of pat...
Isolation of a hemoglobin-derived opioid peptide from cerebrospinal fluid of patients with cerebrovascular bleedings.
Biochem Biophys Res Commun. 1992 Apr 30 ;184(2):1060-6.

PubMed
HER2 status in breast cancer determined by IHC and FISH: comparison of the resul...
HER2 status in breast cancer determined by IHC and FISH: comparison of the results.
Pol J Pathol. 2004 ;55(4):165-71.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Emerging analgesics in cancer pain management.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Education

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information