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    Breast Cancer Res Treat. 2005 Feb;89(3):309-12.

    HER2 codon 655 polymorphism and breast cancer: results from kin-cohort and case-control analyses.

    Millikan RC, Hummer AJ, Wolff MS, Hishida A, Begg CB.

    Source

    Department of Epidemiology, School of Public Health, University of North Carolina, CB #7435, Chapel Hill, NC 27599-7435, USA. millikan@email.unc.edu

    Abstract

    Several published epidemiologic studies show increased breast cancer risk for carriers of the Val-allele at codon 655 of the HER2 gene. We conducted additional analyses using data from three studies, including case-control analyses stratified on age and kin-cohort analyses using relatives of cases and controls. The results provide additional evidence that HER2 codon 655 genotype may predispose to early-onset breast cancer.

    PMID:
    15754131
    [PubMed - indexed for MEDLINE]

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