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Ann N Y Acad Sci. 2004 Dec;1031:391-4.

Gamma-tocotrienol metabolism and antiproliferative effect in prostate cancer cells.

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  • 1University of Perugia, Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, Via del Giochetto, 06126 Perugia, Italy. f.galli@unipg.it


In this study, we evaluated the antiproliferative effect of tocotrienols (T3) and the presence of a specific vitamin E metabolism in PC3 and LNCaP prostate cancer cells. These cell lines are able to transform tocopherols (T) and T3 in the corresponding carboxyethyl-hydroxychromans metabolites (CEHCs). The extent of this metabolism and the inhibitory effect on cell growth followed the order of magnitude alpha-T<alpha-T3<gamma-T<gamma-T3. The partial inhibition of gamma-T3 metabolism by ketoconazole did not influence cell proliferation. These early findings may suggest that the transformation of vitamin E to CEHC is mostly a detoxification mechanism useful to maintain the malignant properties of prostate cancer cells.

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