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    Haematologica. 2005 Mar;90(3):ECR14.

    Pentostatin (2'-deoxycoformycin) for the treatment of hepatosplenic gammadelta T-cell lymphomas.

    Corazzelli G, Capobianco G, Russo F, Frigeri F, Aldinucci D, Pinto A.

    Source

    Hematology-Oncology Unit, Istituto Nazionale Tumori, Fondazione G. Pascale, IRCCS, Via Mariano Semmola, I-80131, Naples, Italy.

    Abstract

    We report the results of treatment with single agent 2'-deoxycoformycin (Pentostatin) in two patients with Hepatosplenic gammadelta T-cell lymphoma (HSgammadeltaTCL), a rare lymphoma subtype with a highly unfavorable prognosis. Present and previous data reviewed here demonstrates the striking cytotoxic activity of Pentostatin against gammadelta+ tumor T cells. Further studies are warranted to define the optimal strategy to fully exploit therapeutic potential of this drug in patients with HSgammadeltaTCL.

    PMID:
    15753055
    [PubMed - indexed for MEDLINE]
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