Trends Biochem Sci. 2005 Mar;30(3):151-9.

The RIP kinases: crucial integrators of cellular stress.

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Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland.

Abstract

Since the discovery of the first member ten years ago, the receptor-interacting protein (RIP) family kinases have emerged as essential sensors of cellular stress. The different members integrate both extracellular stress signals transmitted by various cell-surface receptors and signals emanating from intracellular stress. The cascades of events initiated by activated RIPs are complex. Not only are pro-survival, inflammatory and immune responses triggered by RIP kinases via the activation of transcription factors such as NF-kappaB and AP-1, but opposing, death-inducing programs can also be initiated by the RIP kinases. Hence, RIP kinases are crucial regulators of cell survival and cell death.

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The RIP kinases: crucial integrators of cellular stress.
The RIP kinases: crucial integrators of cellular stress.
Trends Biochem Sci. 2005 Mar ;30(3):151-9.

PubMed
The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits ...
The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation.
Immunity. 2000 Apr ;12(4):419-29.

PubMed
The death domain kinase RIP mediates the TNF-induced NF-kappaB signal.
The death domain kinase RIP mediates the TNF-induced NF-kappaB signal.
Immunity. 1998 Mar ;8(3):297-303.

PubMed
TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signal...
TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex.
Immunity. 1996 Apr ;4(4):387-96.

PubMed
RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fa...
RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis.
EMBO J. 1996 Nov 15 ;15(22):6189-96.

PubMed

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The RIP kinases: crucial integrators of cellular stress.

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