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Department of Pharmacology, Lagos State University College of Medicine, P.M.B. 21266, Ikeja, Lagos, Nigeria. kayodeyemitan@yahoo.com
The saline leaf extract of Bryophyllum pinnatum was investigated on neuropharmacological activities to ascertain claims of local use. When tested in mice, it produced a dose-dependent prolongation of onset and duration of pentobarbitone-induced hypnosis, reduction of exploratory activities in the head-dip and evasion tests. Moreover, a dose-dependent muscle in-coordination was observed in the inclined screen, traction and climbing tests. It delayed onset to convulsion in both strychnine- and picrotoxin-induced seizures in addition to minimal protection against picrotoxin seizures.
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