Management of excessive tearing as a side effect of docetaxel

Bita Esmaeli

doi:10.3816/cbc.2005.n.004

Management of excessive tearing as a side effect of docetaxel

Clin Breast Cancer. 2005 Feb;5(6):455-7. doi: 10.3816/cbc.2005.n.004.

Author

Bita Esmaeli¹

Affiliation

¹ Section of Ophthalmology, Department of Plastic Surgery, Unit 443, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA. besmaeli@mdanderson.org

PMID: 15748466
DOI: 10.3816/cbc.2005.n.004

Abstract

Docetaxel is a highly effective chemotherapeutic agent for metastatic or locally advanced breast cancer as well as other malignancies. One of the side effects of weekly administration of docetaxel is epiphora (excessive tearing) caused by canalicular stenosis and nasolacrimal duct obstruction. This article summarizes experience with epiphora and canalicular stenosis as a side effect of docetaxel and provides specific recommendations for management of this side effect.

Publication types

Review

MeSH terms

Antineoplastic Agents, Phytogenic / adverse effects*
Antineoplastic Agents, Phytogenic / therapeutic use
Breast Neoplasms / drug therapy*
Conjunctivitis / chemically induced
Conjunctivitis / therapy
Constriction, Pathologic
Docetaxel
Female
Humans
Lacrimal Apparatus Diseases / chemically induced*
Lacrimal Apparatus Diseases / therapy*
Taxoids / adverse effects*
Taxoids / therapeutic use

Substances

Antineoplastic Agents, Phytogenic
Taxoids
Docetaxel