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Cleft Palate Craniofac J. 2005 Mar;42(2):192-6.

Bilateral asymmetry in Chinese families with cleft lip with or without cleft palate.

Author information

  • 1Department of Oral and Maxillofacial Surgery and Division of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA. neiswank@sdmgenetics.pitt.edu

Abstract

OBJECTIVE:

To determine if Chinese individuals with nonsyndromic cleft lip with or without cleft palate (CL/P) display more bilateral asymmetry than do their unaffected relatives.

DESIGN/SUBJECTS:

A case-control study of 313 individuals with CL/P from Shanghai, China, with 201 unaffected relatives as controls.

METHODS:

Size-adjusted asymmetry scores were defined by data on middle-finger length, palm length, palpebral fissure width, and ear length. Case-control comparisons used a multivariate repeated measures analysis of variance, paired t tests, and the Wilcoxon signed rank test.

RESULTS:

The ear-length measure showed a significant increase in fluctuating asymmetry (FA) in individuals with CL/P compared with their unaffected relatives, which was most pronounced in the female cleft lip and palate subgroup (p = .04). No other measures showed any increase in FA.

CONCLUSION:

Evidence was found for increased FA, as measured by overall ear length, in Chinese individuals with nonsyndromic CL/P, compared with their unaffected family members. The use of bilateral measurements other than dermatoglyphics may prove to be a valuable means of assessing overall developmental stability in individuals with developmental malformations and in their families.

PMID:
15748111
[PubMed - indexed for MEDLINE]
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