J Biol Chem. 2005 Apr 22;280(16):15485-8. Epub 2005 Mar 3.

Structural clues to Rab GTPase functional diversity.

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Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305-5307, USA. pfeffer@stanford.edu

Abstract

Rab GTPases are key regulators of membrane trafficking in eukaryotes. Recent structural analysis of a number of Rabs, either alone or in complex with partner proteins, has provided new insight into the importance of both conserved and non-conserved features of these proteins that specify their unique functions and localizations. This review will highlight what we have learned from crystallographic analysis of this important protein family.

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Structural clues to Rab GTPase functional diversity.

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