15745859 2005 03 04 2005 04 20 2005 11 16 1471-4906 26 3 2005 Mar Trends in immunology Trends Immunol. Immunodominance of HIV-1-specific CD8(+) T-cell responses in acute HIV-1 infection: at the crossroads of viral and host genetics. 166-71 The development of HIV-1-specific CD8(+) T-cell responses during acute HIV-1 infection is associated with a dramatic decline in HIV-1 replication and the resolution of the acute retroviral syndrome. These HIV-1-specific CD8(+) T cells typically target a small number of viral epitopes in a distinct hierarchical order, and high-level viremia in chronic progressive infection leads to broadly diversified HIV-1-specific CD8(+) T-cell responses with a less clear immunodominance pattern. It is argued here that the specific hierarchical pattern of immune responses in acute HIV-1 infection is the result of a tightly regulated process that, among other factors, is critically impacted by the kinetics of viral protein expression, the HLA class I background of the infected individual and the autologous sequence of the infecting virus. Lichterfeld Mathias M Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA 02129, USA. Yu Xu G XG Le Gall Sylvie S Altfeld Marcus M eng Journal Article Review England Trends Immunol 100966032 1471-4906 0 Histocompatibility Antigens Class I IM Acute Disease Animals CD8-Positive T-Lymphocytes immunology HIV Infections genetics immunology virology HIV-1 genetics immunology Histocompatibility Antigens Class I genetics immunology Humans 62 2005359020054219020053590ppublishS1471-4906(05)00020-710.1016/j.it.2005.01.00315745859
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Trends Immunol. 2005 Mar;26(3):166-71.

Immunodominance of HIV-1-specific CD8(+) T-cell responses in acute HIV-1 infection: at the crossroads of viral and host genetics.

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  • 1Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA 02129, USA.

Abstract

The development of HIV-1-specific CD8(+) T-cell responses during acute HIV-1 infection is associated with a dramatic decline in HIV-1 replication and the resolution of the acute retroviral syndrome. These HIV-1-specific CD8(+) T cells typically target a small number of viral epitopes in a distinct hierarchical order, and high-level viremia in chronic progressive infection leads to broadly diversified HIV-1-specific CD8(+) T-cell responses with a less clear immunodominance pattern. It is argued here that the specific hierarchical pattern of immune responses in acute HIV-1 infection is the result of a tightly regulated process that, among other factors, is critically impacted by the kinetics of viral protein expression, the HLA class I background of the infected individual and the autologous sequence of the infecting virus.

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