[Recognition of virus infected cells by NK cells]

Hisashi Arase; Ikuo Shiratori

doi:10.2222/jsv.54.153

[Recognition of virus infected cells by NK cells]

Uirusu. 2004 Dec;54(2):153-60. doi: 10.2222/jsv.54.153.

[Article in Japanese]

Authors

Hisashi Arase¹, Ikuo Shiratori

Affiliation

¹ Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka University 3-1 Yamadaoka, Suita, 565-0871, Japan. arase@biken.osaka-u.ac.jp

PMID: 15745152
DOI: 10.2222/jsv.54.153

Abstract

NK cells show cytotoxicity against virus-infected cells and tumor cells and play an important role in host defense. Although mecheanism of target cell recognition by NK cells have been unclear for a long time, it has recently been elucidated that certain NK cell receptors specifically recognize virus products. Furthermore, expression pattern of NK cell receptors, which consist of activating and inhibitory receptors, determines susceptibility to virus-infection. Here, we review recent progress of mechanism of recognition of virus-infected by NK cells.

Publication types

Review

MeSH terms

Animals
Antigens, CD
Antigens, Surface / immunology
Evolution, Molecular
Histocompatibility Antigens Class I / immunology
Humans
Killer Cells, Natural / immunology*
Membrane Glycoproteins / immunology
Orexin Receptors
Receptors, Cell Surface
Receptors, Immunologic / immunology
Receptors, Immunologic / physiology
Signal Transduction
Virus Diseases / immunology
Viruses / immunology*

Substances

Antigens, CD
Antigens, Surface
CD200 receptor, mouse
CD200R1 protein, human
Cd200r1 protein, mouse
Histocompatibility Antigens Class I
Membrane Glycoproteins
Orexin Receptors
Receptors, Cell Surface
Receptors, Immunologic
antigens, CD200